How to determine friability of pharmaceutical tablets
Video Source: Professor Tusharhttps://www.youtube.com/watch?v=JbeuwFqqu_w
This video describes method of determination of friability of pharmaceutical tablet dosage form.
Friability is one of the quality control test for tablet dosage form. Friability represents mechanical strength of the tablets. The tablets prepared should exhibit sufficient mechanical strength so that it can bear stresses during transportation.
Tablets are type of solid dosage form for oral administration. They are unit compressed solid dosage form. Tablets contain active pharmaceutical ingredients along with excipients performing various functions such as binder, lubricants, disintegrating agents, glidants and many more.
Procedure: For determination of friability, 0.65 grams of tablets are taken. If the average weight of tablets is more than 0.65 gram, then 10 tablets are taken. Initially weight of tablets are determined, then they are tumbled in a friabilator for 4 minutes at 100 rpm. After that, weight of tablets is taken and friability is determined from the formula given in the video. Tablets passes the friability test if the loss of weight is not more than 1 %. If the tablets are chipped or broken during friability test, then the tablets fail the friability test.